{"created":"2023-06-20T15:54:35.635906+00:00","id":9873,"links":{},"metadata":{"_buckets":{"deposit":"1cf620b3-0548-43c2-98fc-680f19e6990a"},"_deposit":{"created_by":39,"id":"9873","owners":[39],"pid":{"revision_id":0,"type":"depid","value":"9873"},"status":"published"},"_oai":{"id":"oai:redcross.repo.nii.ac.jp:00009873","sets":["98:61:269"]},"author_link":["16043","26983","34065","5429","7191","34064"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-03-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"22","bibliographicPageStart":"17","bibliographicVolumeNumber":"39","bibliographic_titles":[{"bibliographic_title":"高山赤十字病院紀要"},{"bibliographic_title":"Japanese Red Cross Takayama Hospital","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"顎顔面口腔領域の非器質性疼痛の代表的疾患である舌痛症は未だその原因は明確ではない。外来診療に於いては、その診断と治療に最も苦慮する疾患のひとつである。今回、過去３年間に当科外来を受診した非器質性疼痛を訴えた35例の舌痛症（内６例は同時に口腔乾燥も訴えた）と過緊張に起因すると思われた口腔乾燥症の３症例を対象疾患として、SSRIであるエスシタロプラムを投与し加療した。寛解率は67.8%で、半数の症例が２週間以内に寛解した。\n　従来、非器質性疼痛患者にSSRIやSNRIを投薬した場合、その効果発現は下降性疼痛抑制系の賦活と言われている。然しながら、fMRIやPETでの研究がなされるようになり、中脳辺縁系ドパミンシステムの賦活により内因性オピオイドを分泌するシステムの関与が大きいことが分かって来た。本稿では、SSRIであるエスシタロプラムを投与することにより、どのような作用機序で疼痛抑制がなされるかを推論した。","subitem_description_type":"Abstract"},{"subitem_description":"As for the glossodynia which is the typical affection of the non- organic-pain of the maxilla-facial area, the cause isn't clear yet.  In the ambulatory-practice, it is one of the affections most anxiously in the diagnosis and at the medical treatment. \nIn 3 years of the pasts, We treated with Escitalopram of  SSRI  for  35 examples of the glossodynia ( the internal 6 example complained of the dry-mouth, too, at the same time ) which complained of the non- organic-pain and  3 examples of dry mouth which is coused by overstressing.  The half example did a remission rate  within two weeks at 67.8 %.\nUsually, the effect manifestation is recognized that it does the activation of the descending pain modulation system in SSRI and SNRI by the non- organic-pain patient.\nWhile, the research by fMRI and PET became accomplished and it found the thing that the involvement of the system which secretes an endogenous-opioid peptide  by the activation of the  endogenic  dopamine system is concerned.\nIt reasoned by what action mechanism a dolor arrest was accomplished by prescribing Escitalopram  which is SSRI at this article.","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"高山赤十字病院"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0387-7027","subitem_source_identifier_type":"ISSN"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大久保, 恒正"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"安藤, 寿博"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"垣内, 無一"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-07-05"}],"displaytype":"simple","filename":"05大久保恒正.pdf","filesize":[{"value":"3.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"takayama39_005","url":"https://redcross.repo.nii.ac.jp/record/9873/files/05大久保恒正.pdf"},"version_id":"43e25862-3870-490b-b074-3f574ef77a1b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"舌痛症","subitem_subject_scheme":"Other"},{"subitem_subject":"エスシタロプラム","subitem_subject_scheme":"Other"},{"subitem_subject":"内因性オピオイドペプチド","subitem_subject_scheme":"Other"},{"subitem_subject":"Glossodynia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Escitalopram","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Endogenic opioid system","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"口腔顔面領域の非器質性疼痛に対する抗うつ薬の作用機序：第２報","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"口腔顔面領域の非器質性疼痛に対する抗うつ薬の作用機序：第２報"},{"subitem_title":"The Mechanism of Antidepressant to the Non-Organic-Pain in the Mouth and Face Area: 2nd report","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"39","path":["269"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-07-05"},"publish_date":"2016-07-05","publish_status":"0","recid":"9873","relation_version_is_last":true,"title":["口腔顔面領域の非器質性疼痛に対する抗うつ薬の作用機序：第２報"],"weko_creator_id":"39","weko_shared_id":-1},"updated":"2023-06-20T19:28:46.537128+00:00"}