{"created":"2023-06-20T15:51:56.783596+00:00","id":5789,"links":{},"metadata":{"_buckets":{"deposit":"0237cab9-4190-4b07-9d2c-512dbb05d81d"},"_deposit":{"created_by":29,"id":"5789","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"5789"},"status":"published"},"_oai":{"id":"oai:redcross.repo.nii.ac.jp:00005789","sets":["95:28:202"]},"author_link":["16487","16486","16485","16484","7594","18591"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"52","bibliographicPageStart":"49","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"静岡赤十字病院研究報"},{"bibliographic_title":"Journal of Japanese Red Cross Shizuoka Hospital","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"症例は78歳女性．平成5年に2型糖尿病と診断された．その後，平成22年12月にインスリン抗体陽性を確認．血糖変動パターンからBrittle型糖尿病と考えられた．当初は，経口血糖降下剤（OHA）による加療，インスリン強化療法を行っていたが，抗体陽性確認後は，DPP4阻害薬を主軸としたOHAによる治療や，前回と異なる製剤を用いたインスリン強化療法と，治療法の工夫・変更を行った．しかし，いずれも一時的な血糖コントロールが得られるのみで，長期的な治療効果は不十分であった．平成25年1月，外因性インスリン投与は中止とし，GLP-1アナログ製剤であるリラグルチドの投与を開始した．同剤を段階的に増量したところ徐々に良好な血糖コントロールが得られた．\n　本例では，DPP4阻害剤投与で，不十分ではあるがある程度の奏功を認めていた．そこで，同じインクレチン作用による内因性インスリン賦活を期待してGLP-1アナログ製剤の投与を行ったところ，良好な結果を得ることができた．比較的まれな病態に，効果的な治療が適応できたため報告する．","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"静岡赤十字病院"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0911-9833","subitem_source_identifier_type":"ISSN"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"都築, 伸佳"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"土肥, 浩太郎"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"竹丸, 雅志"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"坂巻, 裕介"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"久保田, 英司"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-09-18"}],"displaytype":"simple","filename":"jrcsh3301_49-52.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"pdf003339","url":"https://redcross.repo.nii.ac.jp/record/5789/files/jrcsh3301_49-52.pdf"},"version_id":"8f0b0bf6-8c62-48e7-a7f9-10d52701b2fe"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"強皮症","subitem_subject_scheme":"Other"},{"subitem_subject":"肺サルコイドーシス","subitem_subject_scheme":"Other"},{"subitem_subject":"非乾酪性類上皮細胞肉芽腫","subitem_subject_scheme":"Other"},{"subitem_subject":"anti-insulin antibody","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Brittle diabetes mellitus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"GLP-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"incretin","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"GLP-1アナログ製剤導入により血糖コントロールが得られたBrittle型糖尿病の1例","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"GLP-1アナログ製剤導入により血糖コントロールが得られたBrittle型糖尿病の1例"},{"subitem_title":"GLP-1 Analogues improved in Glycemic Control in a Patient of Brittle Diabetes Mellitus：A Case Report","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"29","path":["202"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-09-18"},"publish_date":"2014-09-18","publish_status":"0","recid":"5789","relation_version_is_last":true,"title":["GLP-1アナログ製剤導入により血糖コントロールが得られたBrittle型糖尿病の1例"],"weko_creator_id":"29","weko_shared_id":-1},"updated":"2023-06-20T20:31:41.619242+00:00"}