{"created":"2023-06-20T15:50:33.663697+00:00","id":3377,"links":{},"metadata":{"_buckets":{"deposit":"1e381de7-2f95-45ac-88a0-97459be58a79"},"_deposit":{"created_by":18,"id":"3377","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"3377"},"status":"published"},"_oai":{"id":"oai:redcross.repo.nii.ac.jp:00003377","sets":["99:64:117"]},"author_link":["256","380","8131","8132","129","8130","192","7396"],"item_5_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-03-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"115","bibliographicPageStart":"110","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"徳島赤十字病院医学雑誌"},{"bibliographic_title":"Tokushima Red Cross Hospital Medical Journal","bibliographic_titleLang":"en"}]}]},"item_5_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"34歳男性．HBe 抗原陽性B 型慢性肝炎（GPT200U/L）の診断でラミブジンを投与開始されたところ，HBV-DNA陰性化，GPT は一時正常化したが30‐50U/L で経過し，HBV-DNA は6.0log.copies 以上であり，肝炎沈静化のまま経過していた．再びHBV-DNA 陽性化，GPT 再上昇した．HBV はYMDD 変異株（YIDD）と確認され，ラミブジン耐性株による肝炎の急性増悪として当科に紹介された．数日間の入院安静でGPT は改善傾向を示し退院するも，外来で経過観察中，1ヵ月後に再びGPT が1554U/L と急上昇した（HBV-DNA：7.2LGE/ml）．入院安静にてGPT，ウイルス量ともに改善傾向を示した．肝炎改善維持のためスミフェロン600万単位を連日投与した．その後も肝炎は沈静化を続け，フミフェロン投与後20日目にGPT 正常化，HBV-DNA 陰性化（TMA 法）に至った．GPT 正常，DNA 陰性はその後も持続し12ヵ月後にHBe 抗体へのseroconversion を認めた．","subitem_description_type":"Abstract"}]},"item_5_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifierScheme":"WEKO"}],"names":[{"name":"SUMIKURA, 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