{"created":"2023-06-20T15:50:23.182456+00:00","id":3096,"links":{},"metadata":{"_buckets":{"deposit":"b232c8ad-5bad-4d6a-87bf-54761656db46"},"_deposit":{"created_by":18,"id":"3096","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"3096"},"status":"published"},"_oai":{"id":"oai:redcross.repo.nii.ac.jp:00003096","sets":["99:64:68"]},"author_link":["228","46","96","6664","6663","6672"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-03-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"16","bibliographicPageStart":"12","bibliographicVolumeNumber":"14","bibliographic_titles":[{"bibliographic_title":"徳島赤十字病院医学雑誌"},{"bibliographic_title":"Tokushima Red Cross Hospital Medical Journal","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"原発性マクログロブリン血症に対するrituximab の効果を未治療患者4例で検討した．いずれの症例も血清中のモノクローナルIgM の存在と骨髄でのリンパ形質細胞の浸潤を確認し，診断した．Rituximab は標準容量（375mg/m２）4回の単独投与を2例，cladribineとの併用投与を2例に施行した．治療効果は50％以上M 蛋白の減少を認めたpartial\r\nresponse は単独投与の1例，25％以上50％未満の減少を認めたminor response は単独投与の１例と併用投与の1例，25％以上増加を認めたprogressive disease が併用投与の1例であった．症例ごとに投与方法や期間は異なるものの，rituximab はマクログロブリン血症に対して有効であった．しかし単独投与による治療効果は限定的で効果の持続期間は約8ヶ月であった．今後，化学療法との併用や維持療法の検討が望まれる．","subitem_description_type":"Abstract"}]},"item_10002_heading_23":{"attribute_name":"見出し","attribute_value_mlt":[{"subitem_heading_banner_headline":"原著","subitem_heading_language":"ja"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"徳島赤十字病院"}]},"item_10002_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"徳島赤十字病院"}],"subitem_relation_type_id":{}}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-9878","subitem_source_identifier_type":"ISSN"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"尾崎, 敬治"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"原, 朋子"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"近藤, 絵里"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"藤野, 修"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"後藤, 哲也"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2013-02-05"}],"displaytype":"simple","filename":"trchmj1401_12-16.pdf","filesize":[{"value":"747.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"pdf001970","url":"https://redcross.repo.nii.ac.jp/record/3096/files/trchmj1401_12-16.pdf"},"version_id":"4af83e2a-9196-4eb3-a9c8-1a7eb7299186"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"原発性マクログロブリン血症","subitem_subject_scheme":"Other"},{"subitem_subject":"rituximab","subitem_subject_scheme":"Other"},{"subitem_subject":"anti‐CD２０モノクローナル抗体","subitem_subject_scheme":"Other"},{"subitem_subject":"Waldenstr¨om’ s macroglobulinemia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"rituximab","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"anti-CD２０monoclonal antibody","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"原発性マクログロブリン血症に対するrituximabの治療効果：当科4例での検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"原発性マクログロブリン血症に対するrituximabの治療効果：当科4例での検討"},{"subitem_title":"Therapeutic efficacy of rituximab in patients with Waldenstr¨om's macroglobulinemia:A single institution experience of four cases","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"18","path":["68"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-02-05"},"publish_date":"2013-02-05","publish_status":"0","recid":"3096","relation_version_is_last":true,"title":["原発性マクログロブリン血症に対するrituximabの治療効果：当科4例での検討"],"weko_creator_id":"18","weko_shared_id":18},"updated":"2023-06-20T21:58:01.407049+00:00"}