{"created":"2023-06-20T16:00:10.825817+00:00","id":18480,"links":{},"metadata":{"_buckets":{"deposit":"2bfa185a-5b14-406a-8152-a24cb34b57bd"},"_deposit":{"created_by":53,"id":"18480","owners":[53],"pid":{"revision_id":0,"type":"depid","value":"18480"},"status":"published"},"_oai":{"id":"oai:redcross.repo.nii.ac.jp:00018480","sets":["615:616:715"]},"author_link":["69796","69791","69795","69794","69797","69792","69793","69798","69790"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-11-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"44","bibliographicPageStart":"38","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"岡山赤十字病院医学雑誌"},{"bibliographic_title":"The Okayama Red Cross Hospital Journal of Medicine","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"2019年6 月に次世代シーケンサー（NGS）を用いた新たながん遺伝子パネル検査が保険収載されたことで，全国的にがん遺伝子パネル検査数は年々増加している．遺伝子検査に用いる検体は従来，未固定検体であったが，近年ホルマリン固定パラフィン包埋（FFPE）検体を用いた検査が可能になった．それにより，今まで以上に検体の取り扱いを厳密に管理する必要が出てきた．当院は2021年度にがんゲノム医療連携病院に指定され，2022年度よりがんゲノム外来を開始している．今後増加するであろうNGS を用いたがん遺伝子パネル検査のために，核酸品質を担保する必要があると考えた．今回，当院から包括的がんゲノムプロファイリング（CGP）検査目的に岡山大学病院へ提出した固形がん検体23件のうち，核酸品質の確認（QC）を実施した検体17件の結果をもとに，FFPE 検体の作製プロセスの見直し，変更を行った．その結果，プロセス変更後において検体の核酸品質に改善がみられた．\n","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"岡山赤十字病院"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0915-8073","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"梅野, 里奈"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"田村, 麻衣子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"都地, 友紘"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"伊東, 優花"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"石﨑, 愛理"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"増田, 雅史"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"斎藤, 利江子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"林, 栄子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"林, 敦志"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-01-31"}],"displaytype":"simple","filename":"03　原著06　梅野 p.38-44.pdf","filesize":[{"value":"2.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"okayama000060","url":"https://redcross.repo.nii.ac.jp/record/18480/files/03　原著06　梅野 p.38-44.pdf"},"version_id":"6f984d80-ef9e-4070-a97e-537bfafcab7e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"formalin-fixed paraffin-embedded ; FFPE","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"next-generation sequencers ; NGS","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"comprehensive genomic profiling ; CGP","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"quality control ; QC","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"がん遺伝子検査において重要な核酸品質保持を目的としたFFPE 検体作製プロセスの見直しと改善について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"がん遺伝子検査において重要な核酸品質保持を目的としたFFPE 検体作製プロセスの見直しと改善について"},{"subitem_title":"Review and improvement of formalin-fixed paraffin-embedded sample preparation procedure for nucleic acid quality control which is essential for genetic testing for cancer","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"53","path":["715"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-02-01"},"publish_date":"2023-02-01","publish_status":"0","recid":"18480","relation_version_is_last":true,"title":["がん遺伝子検査において重要な核酸品質保持を目的としたFFPE 検体作製プロセスの見直しと改善について"],"weko_creator_id":"53","weko_shared_id":-1},"updated":"2023-06-20T17:39:27.523331+00:00"}