{"created":"2023-06-20T15:59:53.399501+00:00","id":18020,"links":{},"metadata":{"_buckets":{"deposit":"a6aa2b9c-dff4-4733-bf70-5c2f6402da40"},"_deposit":{"created_by":41,"id":"18020","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"18020"},"status":"published"},"_oai":{"id":"oai:redcross.repo.nii.ac.jp:00018020","sets":["340","340:341","340:341:682"]},"author_link":["68578","68577","68576","68574","68579","68573","68575"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-04-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"72","bibliographicPageStart":"69","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"高知赤十字病院医学雑誌"},{"bibliographic_title":"Medical Journal of Japanese Red Cross Kochi Hospital","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"症例は 52 歳，女性．右背部痛のため前医を受診し，胸部 CT で多発肺結節と前縦隔腫瘍を認\nめ，精査目的で当科紹介となった．右上葉胸膜直下の肺結節で CT ガイド下生検を行い，病理学的\nに胸腺原発扁平上皮癌と診断し，全身検索の結果，正岡分類Ⅳ b 期と診断した．CBDCA ＋ PTX を\n投与し，2 コース実施後の効果は縮小傾向の SD であったが，6 コース終了後には既存肺結節の再増大\nを認め，PD と判断した．二次治療として，VEGF 受容体，FGF 受容体等の受容体チロシンキナーゼ\nの阻害薬であるレンバチニブを選択し，Ｘ年 5 月から 24mg/ 日の投与を開始した．高血圧症，浮腫，\n手足症候群，蛋白尿，血小板減少などの有害事象のため，レンバチニブの休薬と減量を要し，投与開\n始から 2 か月後に，レンバチニブの投与量は 10mg/ 日になったが，CT で前縦隔腫瘍の縮小と多発肺\n結節の縮小・消失を認め PR を確認した．切除不能な再発胸腺癌症例において，レンバチニブは有効\nで忍容性があった．","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"高知赤十字病院"}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"高知赤十字病院"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0919-7427","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"安田, 早耶香"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"豊田, 優子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"坂東, 弘基"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"森田, 優"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"岡本, 悠里"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"伊藤, 悟志"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"頼田, 顕辞"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-04-20"}],"displaytype":"simple","filename":"切除不能胸腺癌の二次治療としてレンバチニブが奏功した一例.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_9","mimetype":"application/pdf","url":{"label":"高知赤十字病院医学雑誌Vol.26-10","url":"https://redcross.repo.nii.ac.jp/record/18020/files/切除不能胸腺癌の二次治療としてレンバチニブが奏功した一例.pdf"},"version_id":"ee2540a7-4256-4b97-9317-bc9ae391b06b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"胸腺癌","subitem_subject_scheme":"Other"},{"subitem_subject":"レンバチニブ","subitem_subject_scheme":"Other"},{"subitem_subject":"チロシンキナーゼ阻害薬","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"切除不能胸腺癌の二次治療としてレンバチニブが奏功した一例","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"切除不能胸腺癌の二次治療としてレンバチニブが奏功した一例"}]},"item_type_id":"10001","owner":"41","path":["340","341","682"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-04-20"},"publish_date":"2022-04-20","publish_status":"0","recid":"18020","relation_version_is_last":true,"title":["切除不能胸腺癌の二次治療としてレンバチニブが奏功した一例"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2023-06-20T17:48:32.041761+00:00"}