@article{oai:redcross.repo.nii.ac.jp:00018008,
 author = {Yorita, kenji and Hirano, Koki and Kai, Yuka and Tanaka, Yu and Takahashi, Yohei and Arii, Kaoru},
 issue = {1},
 journal = {高知赤十字病院医学雑誌, Medical Journal of Japanese Red Cross Kochi Hospital},
 month = {Apr},
 note = {Necrotizing vasculitis (NV), which could be observed in systemic necrotizing vasculitides such
as classic polyarteritis nodosa, is characterized by fibrinoid necrosis, which typically involves the media.
Among the gynecologic organs, the uterine cervix is the most frequent site of vasculitis; NV of the uterine
cervix is usually asymptomatic and unrelated to systemic vasculitis. Pathological differences between
isolated or single-organ NV and systemic necrotizing vasculitides have been rarely evaluated. Thus, this
study aimed to determine the clinicopathological characteristics of NV of the uterine cervix and evaluate
whether affected vessels are pathologically different from those in classic polyarteritis nodosa. We selected
405 cases of conization that were operated from 2003 to 2017 in our hospital, and follow-up data until 2018
was obtained for patients with vasculitis. NV was evaluated with sections stained by hematoxylin and eosin,
elastica van Gieson, phosphotungstic acid-hematoxylin, and immunohistochemistry. Histological specimens
of systemic necrotizing vasculitides were unavailable. NV and lymphocytic vasculitis (LV) of the uterine
cervix were found in, respectively, six (1.5%) and 26 (6.4%) of the 405 cases; no granulomatous vasculitis was
observed. All cases with vasculitis were asymptomatic and uneventful during the follow-up period, which
suggested that the vasculitis of the uterine cervix in our study was single-organ vasculitis. Lymphocytes
were the main inflammatory infiltrates in NV and LV, and neutrophilic infiltrate was inconspicuous. All NV
cases showed subintimal localization of fibrinoid necrosis, which did not involve the media. The NV cases in
our study differ from the typical NV in classic polyarteritis nodosa.},
 pages = {11--18},
 title = {Is the pathological feature of necrotizing vasculitis isolated in the uterine cervix different from that of classic polyarteritis nodosa? A single institutional study},
 volume = {25},
 year = {2022}
}