{"created":"2023-06-20T15:58:52.202736+00:00","id":16528,"links":{},"metadata":{"_buckets":{"deposit":"65165170-c709-48e8-918c-f20405a5b2dd"},"_deposit":{"created_by":39,"id":"16528","owners":[39],"pid":{"revision_id":0,"type":"depid","value":"16528"},"status":"published"},"_oai":{"id":"oai:redcross.repo.nii.ac.jp:00016528","sets":["98:61:579"]},"author_link":["61695","61694","61692","61690","61691","61693","61689"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-03-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"30","bibliographicPageStart":"24","bibliographicVolumeNumber":"43","bibliographic_titles":[{"bibliographic_title":"高山赤十字病院紀要"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"われわれは、非器質性疼痛である舌痛症50例にエスシタロプラムによる薬物療法を試み、早期鎮痛効果の発現に対して、①5-HT増強による下降性疼痛抑制系の賦活、②下降性疼痛抑制系を介するopioid 受容体活性化、③扁桃体及び海馬支脚腹側部から側坐核への負情動ブロック、④5-HT1A受容体刺激による扁桃体の過活動抑制、⑤DA-phasic activity活性化の可能性の５機序を考察した。今回、早期に非器質性疼痛が軽快・消失した10症例の追跡結果を検討し、一部の再燃例から鎮痛効果が減弱する作用機序を上記①～⑤を基に考察した。その結果、④5-HT1A受容体刺激による扁桃体の過活動抑制と②下降性疼痛抑制系を介する opioid 受容体活性化の２項目を非器質性疼痛の抑制機序の主な作用と考えた。更に、非器質性疼痛の再燃には、ESCを反復投与したことにより、5-HT1A 自己受容体の脱感作による 5-HT 神経の活性化が起こり①、②、⑤の機序が効果減弱を来した可能性を推察した。","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"高山赤十字病院"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0387-7027","subitem_source_identifier_type":"ISSN"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大久保, 恒正"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"安藤, 寿博"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大久保, 有"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"垣内, 無一"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"四衢, 崇"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"清島, 満"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"加藤, 秀明"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-07-22"}],"displaytype":"simple","filename":"06臨床・症例検討　5大久保恒正.pdf","filesize":[{"value":"2.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"takayama43_006","url":"https://redcross.repo.nii.ac.jp/record/16528/files/06臨床・症例検討　5大久保恒正.pdf"},"version_id":"81e8a21d-b8df-450e-9cb2-d53e8ec96f5f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"非器質性疼痛","subitem_subject_scheme":"Other"},{"subitem_subject":"舌痛症","subitem_subject_scheme":"Other"},{"subitem_subject":"エスシタロプラム","subitem_subject_scheme":"Other"},{"subitem_subject":"再燃","subitem_subject_scheme":"Other"},{"subitem_subject":"脱感作","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"頭頸部領域の非器質性疼痛に対するエスシタロプラムの早期効 果発現作用機序の推測 ―第２報―　～非器質性疼痛にはSSRI投薬が望ましい～","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"頭頸部領域の非器質性疼痛に対するエスシタロプラムの早期効 果発現作用機序の推測 ―第２報―　～非器質性疼痛にはSSRI投薬が望ましい～"}]},"item_type_id":"10002","owner":"39","path":["579"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-07-22"},"publish_date":"2020-07-22","publish_status":"0","recid":"16528","relation_version_is_last":true,"title":["頭頸部領域の非器質性疼痛に対するエスシタロプラムの早期効 果発現作用機序の推測 ―第２報―　～非器質性疼痛にはSSRI投薬が望ましい～"],"weko_creator_id":"39","weko_shared_id":-1},"updated":"2023-06-20T18:18:47.711334+00:00"}