@article{oai:redcross.repo.nii.ac.jp:00016471, author = {Naoto, Kuroda and Kenji, Yorita and Chisato, Ohe and Fumiyoshi, Kojima and Ikuma, Kato and Shuji, Mikami and Motsuko, Furuya and Yoji, Nagashima and Chin-Chen, Pan and Jose Ignacio, Lopez and Ondrej, Hes and Michal, Michal and Mahul B., Amin}, issue = {1}, journal = {高知赤十字病院医学雑誌, Medical Journal of Japanese Red Cross Kochi Hospital}, month = {Mar}, note = {Epithelioid angiomyolipoma (eAML) is a rare renal neoplasm, in which the proportion of epithelioid cells in eAML accounts for more than 80% of the entire lesion. eAML often occurs with tuberous sclerosis complex as well as a sporadic manner. Histologically, the tumor predominantly consists of epithelioid cells with eosinophilic to clear cytoplasm, frequently showing pleomorphic ganglion-like or multinucleated giant cells. Spindle cells or adipose tissue also proliferate. Perivascular hyalinization and entrapped tubules are frequently identified. Immunohistochemically, neoplastic cells usually show the positivity for melanomarelated antigen (HMB45, HMB50, CD63, and Melan A), and alpha-smooth muscle actin. Ultrastructurally, epithelioid cells contain striated, rhomboid, spherical or elliptical granules which may mimic melanosome, renin granules or rarely form typical premelanosomes. Approximately 40 % of cases with eAML behaves aggressively. As the investigation on indicators of clinical behavior is not enough to date, the accumulation and further examination of cases with eAML is required in the near future.}, pages = {29--34}, title = {Review of renal epithelioid angiomyolipoma with focus on clinical and pathobiological aspects(和訳中)}, volume = {24}, year = {2020} }