{"created":"2023-06-20T15:58:40.418468+00:00","id":16202,"links":{},"metadata":{"_buckets":{"deposit":"cfd5c576-4da2-4772-a54e-f6aa4e059197"},"_deposit":{"created_by":53,"id":"16202","owners":[53],"pid":{"revision_id":0,"type":"depid","value":"16202"},"status":"published"},"_oai":{"id":"oai:redcross.repo.nii.ac.jp:00016202","sets":["615:616:619"]},"author_link":["60367","60368","60365","60369","60370","60366","60371"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-11","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"35","bibliographicPageStart":"30","bibliographicVolumeNumber":"30","bibliographic_titles":[{"bibliographic_title":"岡山赤十字病院医学雑誌"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"　症例は45歳男性．HER2 陽性食道胃接合部癌に対しカペシタビン＋オキサリプラチン併用療法が導入された．食欲不振のためカペシタビンは内服期間2 日で中止となった．その後口内炎Grade3，下痢Grade3，好中球減少Grade4（nadir はday17の9.8/μL），血小板減少Grade4，発熱性好中球減少症を発症したが，加療により回復した．カペシタビンを一段階減量した上，トラスツズマブ＋カペシタビン併用療法へレジメン変更し化学療法を再開した．食欲不振と倦怠感のためカペシタビンは内服期間5 日で中止となった．その後口内炎Grade3，下痢Grade4，好中球減少Grade4（nadir はday17の10/μL），血小板減少Grade4，敗血症，DIC となり多臓器不全にて永眠された．併用薬は異なるが2 レジメンとも同様の経過を辿ったことからカペシタビンによる有害事象であった可能性が高く，短期間の内服で重篤な症状を呈したことからカペシタビン不耐症が疑われた．Dihydropyrimidine dehydrogenase（DPD）欠損症であった可能性も考えられ，フッ化ピリミジン系抗癌薬投与時には本症の存在を念頭に置いた十分な患者説明と医療スタッフへのリスク周知が必要と考えられた．","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"岡山赤十字病院"}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"岡山赤十字病院"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0915-8073","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小池, 彩子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"出宮, 千聖"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"中尾, なつみ"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"永原, 照也"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"井上, 雅文"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小橋, 春彦"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"森, 英樹"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-12-25"}],"displaytype":"simple","filename":"04-3　症例 小池 p.30-35.pdf","filesize":[{"value":"2.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"okayama000019","url":"https://redcross.repo.nii.ac.jp/record/16202/files/04-3　症例 小池 p.30-35.pdf"},"version_id":"8b2b98d4-0417-4c10-a264-7448cac04e61"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Capecitabine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Dihydropyrimidine dehydrogenase deficiency","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"DPD","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Fluoropyrimidine","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"重篤な骨髄抑制と粘膜障害を来しカペシタビン不耐症が疑われた1例","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"重篤な骨髄抑制と粘膜障害を来しカペシタビン不耐症が疑われた1例"}]},"item_type_id":"10001","owner":"53","path":["619"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-12-25"},"publish_date":"2019-12-25","publish_status":"0","recid":"16202","relation_version_is_last":true,"title":["重篤な骨髄抑制と粘膜障害を来しカペシタビン不耐症が疑われた1例"],"weko_creator_id":"53","weko_shared_id":-1},"updated":"2023-06-20T18:30:49.840958+00:00"}