{"created":"2023-06-20T15:56:59.849330+00:00","id":14114,"links":{},"metadata":{"_buckets":{"deposit":"bbe557dc-a298-4c09-bd93-7ed25c9afd5b"},"_deposit":{"created_by":41,"id":"14114","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"14114"},"status":"published"},"_oai":{"id":"oai:redcross.repo.nii.ac.jp:00014114","sets":["340:341:552"]},"author_link":["51195","51199","51196","51201","51200","51197","51202","51194","51192","51193","51203","51198"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographicVolumeNumber":"23","bibliographic_titles":[{"bibliographic_title":"高知赤十字病院医学雑誌"},{"bibliographic_title":"Medical Journal of Kochi Red Cross Hospital","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: The MYB-NFIB fusion gene has recently been detected in adenoid cystic carcinomas (ACCs)\nof the salivary gland and other organs. Detection of MYB rearrangement appears to be diagnostically\nvaluable for ACCs, particularly in high-grade transformed ACCs (HGT-ACCs). However, a consensus\ncutoff value defining MYB rearrangement using fluorescence in situ hybridization (FISH) has not been\nestablished. The aim of this study was to investigate an appropriate evaluation of MYB rearrangement in\nACCs using FISH.\nStudy Design: We retrospectively selected 10 ACC cases diagnosed between 2000 and 2015. FISH\nanalysis was performed using formalin-fixed paraffin-embedded sections and a MetaSystems image\nanalysis system.\nResults: The involved sites were the major salivary gland (n=4), oral cavity (n=2), lip (n=1), nasal cavity\n(n=1), external acoustic meatus (n=1), and trachea (n=1). One case was of HGT-ACC. Six cases (60%)\nincluding the HGT-ACC showed positive MYB rearrangement, exhibiting over 85% split MYB signals.\nThe other cases were negative, demonstrating fewer than 10% split MYB signals, as observed in nonneoplastic\ncells.\nConclusion: The MYB rearrangement cutoff value in ACC cells was 10%. MYB rearrangement\nheterogeneity in ACC cells appeared to not be present. This genetic study supported the diagnosis of\nHGT-ACC.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"高知赤十字病院図書室運営委員会"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0919-7427","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"頼田, 顕辞"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"黒田, 直人"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"吾妻, 美子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"和田, 有加里"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小原, 昌彦"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"安岡, 香"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"水野, 圭子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"福田, 潤弥"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"中川, 英幸"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"宮崎, かつし"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"谷田, 信行"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"浜口, 伸正"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-06-05"}],"displaytype":"simple","filename":"2018高知赤十字病院医学雑誌_賴田Dr.pdf","filesize":[{"value":"613.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Kohi23-1","url":"https://redcross.repo.nii.ac.jp/record/14114/files/2018高知赤十字病院医学雑誌_賴田Dr.pdf"},"version_id":"e39a603b-6686-4be0-9087-49acd9c4e9b3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Adenoid cystic carcinoma","subitem_subject_scheme":"Other"},{"subitem_subject":"MYB rearrangement","subitem_subject_scheme":"Other"},{"subitem_subject":"fluorescent in situ hybridization","subitem_subject_scheme":"Other"},{"subitem_subject":"Adenoid cystic carcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"MYB rearrangement","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"fluorescent in situ hybridization","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Computer-aided automated evaluation of MYB rearrangement in 10 cases of adenoid cystic carcinoma using fluorescent in situ hybridization: a single-institution study(和訳中)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Computer-aided automated evaluation of MYB rearrangement in 10 cases of adenoid cystic carcinoma using fluorescent in situ hybridization: a single-institution study(和訳中)"},{"subitem_title":"Computer-aided automated evaluation of MYB rearrangement in 10 cases of adenoid cystic carcinoma using fluorescent in situ hybridization: a single-institution study(和訳中)","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"41","path":["552"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-06-05"},"publish_date":"2019-06-05","publish_status":"0","recid":"14114","relation_version_is_last":true,"title":["Computer-aided automated evaluation of MYB rearrangement in 10 cases of adenoid cystic carcinoma using fluorescent in situ hybridization: a single-institution study(和訳中)"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2023-06-20T18:31:10.149157+00:00"}