{"created":"2023-06-20T15:56:55.287987+00:00","id":13995,"links":{},"metadata":{"_buckets":{"deposit":"0c7536fe-0d35-4541-a74a-de48b84fe17a"},"_deposit":{"created_by":53,"id":"13995","owners":[53],"pid":{"revision_id":0,"type":"depid","value":"13995"},"status":"published"},"_oai":{"id":"oai:redcross.repo.nii.ac.jp:00013995","sets":["615:616:617"]},"author_link":["50732","50741","50734","50735","50737","50733","50738","50739","50736","50740"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-11","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"57","bibliographicPageStart":"48","bibliographicVolumeNumber":"29","bibliographic_titles":[{"bibliographic_title":"岡山赤十字病院医学雑誌"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Tocilizumab(TCZ)(IL-6阻害薬)による皮疹の副作用については、あまり注目されてこなかった。今回我々はTCZ使用と、重篤な皮膚病変の出現との関連を強く疑わせる症例を経験した。症例は59歳男性、関節リウマチ(RA)に対し、TCZを開始した。その後皮疹が出現し始め、白血球破砕性血管炎の診断に至った。中等量PSL併用後も新たに好中球性皮膚症を発症し、ジアフェニルスルホン(DDS)を追加し寛解していたが、これら薬剤の減量中に再燃し重症化した。ステロイドパルス+高用量PSLを開始したが、右足背の皮疹が増悪し皮膚潰瘍形成に至った。最終的にTCZ関与の可能性を考慮し、TCZ投与は中止した。TCZ投与による皮膚病変増悪のメカニズムは未だ知られていない。我々はTCZ使用が皮膚病変発生にどのように関与し得るかを探索する目的で、TCZを使用したRA患者10例について、使用前後の末梢血遺伝子発現の変化を解析した。有意に発現変化を認めた遺伝子について遺伝子オントロジー解析を行ったところ、TCZ使用により好中球活性化遺伝子が有意に亢進し、創傷治癒に関連する遺伝子は有意に抑制されている事が判明した。(著者抄録)","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"岡山赤十字病院 "}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0915-8073","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大槻, 花穂"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"妹尾, 明美"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"佐藤, 慶治"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"田村, 麻衣子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山口, 麻里"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"深松, 伸明"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"高木, 徹"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"樋口, 俊恵"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"別所, 昭宏"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小山, 芳伸"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-03-14"}],"displaytype":"simple","filename":"03-6　原著 大槻 p.48-57.pdf","filesize":[{"value":"7.4 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"okayama000008","url":"https://redcross.repo.nii.ac.jp/record/13995/files/03-6　原著 大槻 p.48-57.pdf"},"version_id":"bb6c9992-8383-4b59-abc2-7b48a9aebafd"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Tocilizumab","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Rheumatoid Arthritis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Neutrophilic dermatoses","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Skin ulcer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Transcriptome analysis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Tocilizumab(TCZ)使用前後の末梢血トランスクリプトームの変化とTCZ使用中に多彩な皮膚病変をきたした一例","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Tocilizumab(TCZ)使用前後の末梢血トランスクリプトームの変化とTCZ使用中に多彩な皮膚病変をきたした一例"}]},"item_type_id":"10001","owner":"53","path":["617"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-03-14"},"publish_date":"2019-03-14","publish_status":"0","recid":"13995","relation_version_is_last":true,"title":["Tocilizumab(TCZ)使用前後の末梢血トランスクリプトームの変化とTCZ使用中に多彩な皮膚病変をきたした一例"],"weko_creator_id":"53","weko_shared_id":-1},"updated":"2023-06-20T18:49:18.388244+00:00"}