{"created":"2023-06-20T15:56:41.196139+00:00","id":13653,"links":{},"metadata":{"_buckets":{"deposit":"352da6b0-4e7e-420f-80d3-4a567edb767b"},"_deposit":{"created_by":41,"id":"13653","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"13653"},"status":"published"},"_oai":{"id":"oai:redcross.repo.nii.ac.jp:00013653","sets":["340","340:341","340:341:505"]},"author_link":["49884","49881","49885","49878","49886","49882","49876","49887","49883","49879","49877","49880"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"28","bibliographicPageStart":"23","bibliographicVolumeNumber":"22","bibliographic_titles":[{"bibliographic_title":"高知赤十字病院医学雑誌"},{"bibliographic_title":"Medical Journal of Kochi Red Cross Hospital","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland\ntumor. Histological diagnosis of MECs that exhibit classical histological features is not difficult. However,\ndiagnosis of some histological variants or high-grade MEC tumors can be challenging because of overlaps\nin histological features with other diseases. Recently, chromosomal translocations in salivary gland\ntumors have been recognized, and the detection of MAML2 rearrangements can support the pathological\ndiagnosis of MECs. Recently, MECs without MAML2 rearrangements might be reclassified as hyalinizing\nclear cell carcinoma (HCCC) based on the detection of EWSR1 -ATF1 gene fusions. The present study\naimed to investigate the presence of MAML2 and EWSR1 rearrangements in MECs via fluorescence in\nsitu hybridization (FISH).\nMaterials and methods: We retrospectively analyzed tumor samples from five MEC patients diagnosed in\nour hospital between 2008 to 2015. A total of six tumors from the five cases were pathologically evaluated\nand subjected to FISH analysis, which was performed using a MetaSystems image analysis system.\nResults: The median age of the patients was 75 years (range: 32-79), with the majority of patients\nbeing male (male to female ratio, 4:1). The localization and pathological classification (histological\ngrade, histological variant) of the six tumors were parotid gland/low grade/classical histology (n=2),\nsubmandibular gland/low grade/clear cell variant (n=1), lung/high grade (n=1), lung/low grade/classical\n(n=1), and maxillary sinus/low grade/clear cell variant (n=1). Less than 10% of the background nonneoplastic\ncells showed split signals of MAML2 . Positive MAML2 rearrangements were observed in two\nparotid tumors and one maxillary sinus tumor because each tumor showed over 90% of MAML2 split\nsignals. The other tumors appeared to show equivocal results for MAML2 rearrangement. No EWSR1\nrearrangements were detected in all cases, suggesting that HCCC was not present.\nConclusion: FISH was found to be effective for obtaining conclusive MEC diagnoses with small biopsy\nsamples. However, this method may have a high rate of returning equivocal results, thereby limiting its\nuse in confirming the presence of gene rearrangements.","subitem_description_type":"Abstract"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0919-7427","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kenji, Yorita"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Naoto, Kuroda"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshiko, Agatsuma"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yukari, Wada"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Masahiko, Ohara"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kaori, Yasuoka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Keiko, Mizuno"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Junya, Fukuda"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hideyuki, Nakagawa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Katsushi, Miyazaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nobuyuki, Tanida"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nobumasa, Hamaguchi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-20"}],"displaytype":"simple","filename":"2017高知赤十字病院医学雑誌_了-07.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2017高知赤十字病院医学雑誌_了-07","url":"https://redcross.repo.nii.ac.jp/record/13653/files/2017高知赤十字病院医学雑誌_了-07.pdf"},"version_id":"b2926cab-6c99-49dc-92f3-09710b01d493"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Computer-aided automated evaluation of MAML2 and EWSR1 rearrangements in five cases of mucoepidermoid carcinoma: A single-institution study using fluorescence in situ hybridization(和訳中)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Computer-aided automated evaluation of MAML2 and EWSR1 rearrangements in five cases of mucoepidermoid carcinoma: A single-institution study using fluorescence in situ hybridization(和訳中)","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"41","path":["340","341","505"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-20"},"publish_date":"2018-06-20","publish_status":"0","recid":"13653","relation_version_is_last":true,"title":["Computer-aided automated evaluation of MAML2 and EWSR1 rearrangements in five cases of mucoepidermoid carcinoma: A single-institution study using fluorescence in situ hybridization(和訳中)"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2023-06-20T18:55:21.887777+00:00"}