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Detection of MYB rearrangement appears to be diagnostically\nvaluable for ACCs, particularly in high-grade transformed ACCs (HGT-ACCs). However, a consensus\ncutoff value defining MYB rearrangement using fluorescence in situ hybridization (FISH) has not been\nestablished. The aim of this study was to investigate an appropriate evaluation of MYB rearrangement in\nACCs using FISH.\nStudy Design: We retrospectively selected 10 ACC cases diagnosed between 2000 and 2015. FISH\nanalysis was performed using formalin-fixed paraffin-embedded sections and a MetaSystems image\nanalysis system.\nResults: The involved sites were the major salivary gland (n=4), oral cavity (n=2), lip (n=1), nasal cavity\n(n=1), external acoustic meatus (n=1), and trachea (n=1). One case was of HGT-ACC. 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Computer-aided automated evaluation of MYB rearrangement in 10 cases of adenoid cystic carcinoma using fluorescent in situ hybridization: a single-institution study(和訳中)
https://redcross.repo.nii.ac.jp/records/14114
https://redcross.repo.nii.ac.jp/records/14114fea0e222-0cdb-408c-b78f-4c327278b76c
名前 / ファイル | ライセンス | アクション |
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Kohi23-1 (613.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-06-05 | |||||
タイトル | ||||||
タイトル | Computer-aided automated evaluation of MYB rearrangement in 10 cases of adenoid cystic carcinoma using fluorescent in situ hybridization: a single-institution study(和訳中) | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Computer-aided automated evaluation of MYB rearrangement in 10 cases of adenoid cystic carcinoma using fluorescent in situ hybridization: a single-institution study(和訳中) | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Adenoid cystic carcinoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | MYB rearrangement | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | fluorescent in situ hybridization | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Adenoid cystic carcinoma | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | MYB rearrangement | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | fluorescent in situ hybridization | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
頼田, 顕辞
× 頼田, 顕辞× 黒田, 直人× 吾妻, 美子× 和田, 有加里× 小原, 昌彦× 安岡, 香× 水野, 圭子× 福田, 潤弥× 中川, 英幸× 宮崎, かつし× 谷田, 信行× 浜口, 伸正 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objective: The MYB-NFIB fusion gene has recently been detected in adenoid cystic carcinomas (ACCs) of the salivary gland and other organs. Detection of MYB rearrangement appears to be diagnostically valuable for ACCs, particularly in high-grade transformed ACCs (HGT-ACCs). However, a consensus cutoff value defining MYB rearrangement using fluorescence in situ hybridization (FISH) has not been established. The aim of this study was to investigate an appropriate evaluation of MYB rearrangement in ACCs using FISH. Study Design: We retrospectively selected 10 ACC cases diagnosed between 2000 and 2015. FISH analysis was performed using formalin-fixed paraffin-embedded sections and a MetaSystems image analysis system. Results: The involved sites were the major salivary gland (n=4), oral cavity (n=2), lip (n=1), nasal cavity (n=1), external acoustic meatus (n=1), and trachea (n=1). One case was of HGT-ACC. Six cases (60%) including the HGT-ACC showed positive MYB rearrangement, exhibiting over 85% split MYB signals. The other cases were negative, demonstrating fewer than 10% split MYB signals, as observed in nonneoplastic cells. Conclusion: The MYB rearrangement cutoff value in ACC cells was 10%. MYB rearrangement heterogeneity in ACC cells appeared to not be present. This genetic study supported the diagnosis of HGT-ACC. |
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書誌情報 |
高知赤十字病院医学雑誌 en : Medical Journal of Kochi Red Cross Hospital 巻 23, 号 1, p. 1-6, 発行日 2019-03 |
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出版者 | ||||||
出版者 | 高知赤十字病院図書室運営委員会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0919-7427 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |