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The supposition of the mechanism of escitalopram makes a dopamine nerve activity rise by inhibiting corticotropinreleasing factor to the non-organic-pain ~A SSRI application is desirable for a non-organic-pain~
https://redcross.repo.nii.ac.jp/records/16529
https://redcross.repo.nii.ac.jp/records/165298c163958-8fd6-4a31-a374-49bbe97441d8
名前 / ファイル | ライセンス | アクション |
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takayama43_007 (1.5 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2020-07-22 | |||||
タイトル | ||||||
タイトル | The supposition of the mechanism of escitalopram makes a dopamine nerve activity rise by inhibiting corticotropinreleasing factor to the non-organic-pain ~A SSRI application is desirable for a non-organic-pain~ | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Escitalopram | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | A10 nerve | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | non-organic pain | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | descending pain modulatory system | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | βendorphin | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
OHKUBO, Tsunemasa
× OHKUBO, Tsunemasa× KAITO, Muichi× ANDO, Toshihiro× KATO, Hideaki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Although escitalopram (ESC) is no having dopamine (DA) transporter (DAT) inhibitory-action, having dopamine nerve (A10 nerve) stimulus operation by the ESC used basic experiment is reported. We supposed the mechanism that the DA increases and it supposed the mechanism that makes a non-organic pain disappear with ①5-HT reinforcement of the descending pain modulatory system, ②the opioid receptor activation with the descending pain modulatory system, ③negative emotion block from the amygdala and the hippocampus to the nucleus accumbens, ④5-HT1A receptor stimulation from the activation of the amygdala, ⑤DA-phasic activity activation. As a result ④ and ⑤ two items were an operation with a main restraint mechanism of a nonorganic-pain. ESC is different from other SSRIs, and we know that ESC make a DA increase at the VTA. We supposed amygdala that a functional depression declined by corticotropin-releasing factor (CRF) is improved with ④ and ③. After DA stimulate by A10 nerve, DA is undergone metabolic change to, and the endogenous opioid peptide (βendorphin) is made. |
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書誌情報 |
高山赤十字病院紀要 巻 43, p. 31-34, 発行日 2020-03-01 |
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出版者 | ||||||
出版者 | 高山赤十字病院 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0387-7027 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |